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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Substance P
Research Papers that Mention the Interaction
“Local application of capsaicin depletes the peripheral neurons of substance P and may block the conduction of pain or pruritus.”
Hemodialysis-related pruritus: a double-blind, placebo-controlled, crossover study of capsaicin 0.025% cream.“Topical capsaicin depletes and prevents the reaccumulation of substance P in peripheral sensory neurons.”
“The SP released from cultured DRG neurons of Na(v)1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than that from wild-type (C57BL/6) mice based on a radioimmunoassay.”
“During capsaicin therapy , a reduction of neuropeptides ( substance P , calcitonin gene‐related peptide) was observed.”
“Conclusion: Elevated salivary SP concentrations stimulated by capsaicin greatly improve the safety and efficacy of swallowing, and shorten the swallow response in older patients with OD.”
“Salivary SP levels were significantly increased after capsaicin administration compared with placebo in the effective group.”
“In our case report, we propose that the inhibition of substance P release induced by capsaicin plays a role in the disappearance of acne.”
“This activation leads to cellular degranulation by neuropeptides such as substance P. Repeated application of capsaicin inhibits release of substance P , which explains the analgesic effect.”
“ Capsaicin is a natural chilli pepper extract that depletes sensory nerve endings of substance P , a pain neurotransmitter.”
“ Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene‐related peptide (CGRP) and substance P in the stomach.”
“ Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene‐related peptide (CGRP) and substance P in the stomach.”
“The addition of a low dose of capsaicin to liquid or food, which stimulates the release of SP , may help prevent aspiration pneumonia.”
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