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Last Updated: a year ago

Possible Interaction: Capsaicin and Substance P

supplement:

Capsaicin

Research Papers that Mention the Interaction

Local application of capsaicin depletes the peripheral neurons of substance P and may block the conduction of pain or pruritus.
Nephron  •  1996  |  View Paper
Topical capsaicin depletes and prevents the reaccumulation of substance P in peripheral sensory neurons.
Journal of the American Academy of Dermatology  •  1992  |  View Paper
The SP released from cultured DRG neurons of Na(v)1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than that from wild-type (C57BL/6) mice based on a radioimmunoassay.
Journal of pharmacological sciences  •  2008  |  View Paper
During capsaicin therapy , a reduction of neuropeptides ( substance P , calcitonin gene‐related peptide) was observed.
Experimental dermatology  •  2004  |  View Paper
Conclusion: Elevated salivary SP concentrations stimulated by capsaicin greatly improve the safety and efficacy of swallowing, and shorten the swallow response in older patients with OD.
Salivary SP levels were significantly increased after capsaicin administration compared with placebo in the effective group.
Digestion  •  2017  |  View Paper
In our case report, we propose that the inhibition of substance P release induced by capsaicin plays a role in the disappearance of acne.
This activation leads to cellular degranulation by neuropeptides such as substance P. Repeated application of capsaicin inhibits release of substance P , which explains the analgesic effect.
Journal of the European Academy of Dermatology and Venereology : JEADV  •  2010  |  View Paper
Capsaicin is a natural chilli pepper extract that depletes sensory nerve endings of substance P , a pain neurotransmitter.
Prescrire international  •  2010  |  View Paper
Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene‐related peptide (CGRP) and substance P in the stomach.
The Journal of pharmacy and pharmacology  •  2005  |  View Paper
Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene‐related peptide (CGRP) and substance P in the stomach.
The Journal of pharmacy and pharmacology  •  2004  |  View Paper
The addition of a low dose of capsaicin to liquid or food, which stimulates the release of SP , may help prevent aspiration pneumonia.
Internal medicine  •  1997  |  View Paper
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