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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Capsaicin
drug:
Streptozocin
Research Papers that Mention the Interaction
“Here, we report that dietary capsaicin potently inhibits and reverses chronic renal structural and functional damages in db/db or streptozotocin (STZ)-induced diabetic mice in a TRPV1-dependent manner.”
Activation of TRPV1 channel antagonizes diabetic nephropathy through inhibiting endoplasmic reticulum-mitochondria contact in podocytes.“Intrapericardial capsaicin produced fewer EMG responses, which were delayed and reduced in streptozotocin-treated rats compared to controls.”
“Also, streptozotocin treatment induced a reduction in intracellular calcium levels and inhibited capsaicin induced calcium transients and membrane depolarization.”
Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy.
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