Possible Interaction: Capsaicin and Somatostatin

“On the other hand, arterial infusion of capsaicin significantly increased the release of not only CGRP but also somatostatin from the stomach of normal rats.”

“We found that CST and SST do not modify basal CGRP secretion from trigeminal neurons, but both peptides were able to inhibit in a concentration-dependent manner the release of CGRP stimulated by KCl, veratridine or capsaicin.”

“ Capsaicin administration inhibited the stimulated gastrin and histamine secretion and reversed the suppression of somatostatin secretion mediated by vagal stimulation.”

“The intestinal vasodilatatory effect of capsaicin could invariably be demonstrated after pretreatment with adrenoceptor … the increase in intestinal blood flow elicited by capsaicin.4.Concomitant administration of somatostatin … capsaicin injected into the superior mesenteric artery.5.Our results indirectly … fibres associated with the blood vessels of the gastrointestinal tract.”

“ Capsaicin infusions (10-5 M) significantlystimulated both GLP-1, somatostatin , and VIP release to111.1 ± 4.5% (N = 9), 138.0 ± 15.8% (N =9) and 208.3 ± 63.8% (N = 8) of basal release,respectively.”

“Intravenous injection of the putative mediator somatostatin (10 microg/kg) or its analogues RC-160 and TT-232, but not octreotide inhibited the cardiorespiratory and blood pressure responses evoked by topical cutaneous application of mustard oil or capsaicin instillation into the eye.”

“While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level.”

“Neonatal treatment with capsaicin resulted in a drastic reduction of immunoreactivity for SP, PHM, ST14 , 1-14 S28, and in a partial reduction of CGRP-like positive perikarya.”

“These responses were inhibited totally or mostly by capsaicin , administered neonatally, topically, or perineurally, by topical lidocaine, and by parenteral administration of substance P antiserum, somatostatin , or hexamethonium.”

“The response to capsaicin was completely abolished by a previous intraluminal application of the local anesthetic lidocaine, and was inhibited by an intraarterial injection of somatostatin.”