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Possible Interaction: Capsaicin and Serotonin

supplement:

Capsaicin

Research Papers that Mention the Interaction

Similar to PGE(2), an intraplantar injection of capsaicin (0.1 mg) produced a robust thermal hypersensitivity that was paralleled by a 3-fold increase in levels of 5-HT in the RVM.
Brain Research  •  2006  |  View Paper
5-HT (… capsaicin in an insurmountable way.6.The effect of very high concentrations of 5-HT (>10−5 mol/l) could be partially antagonised by … from the ileum of adult guinea-pigs a contractile action of 5-HT can be mediated by the activation of three independent receptors.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Tetrodotoxin (1 µM), NG-nitro-l-arginine (100 µM) and capsaicin (1 µM) were ineffective in antagonising the relaxation induced by 5-HT.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2000  |  View Paper
The scratching induced by 5-HT (100 nmol site(-1), peak effective dose) was suppressed by capsaicin (repeated administration) and the opioid antagonist naloxone, features being similar to human itching.
Neuroscience Research  •  1999  |  View Paper
In intact ilea, however, tetrodotoxin (TTX) and capsaicin reduced significantly the maximum values of Isc stimulated by 5-HT , and the nitric oxide synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) caused a significant decrease in the maximum response to 5-HT.
Acta physiologica Scandinavica  •  1998  |  View Paper
Extracellular concentrations of aspartate, glutamate and serotonin increased significantly following capsaicin injection into the ipsilateral limb.
Brain Research  •  1993  |  View Paper
Responses evoked by brief applications of … threshold concentrations of bradykinin or capsaicin to the … enhanced by 5-hydroxytryptamine and the 5-hydroxytryptamine1C/5-hydroxytryptamine2-receptor agonist alpha-methyl-5-hydroxtryptamine but not by the …-hydroxytryptamine3-receptor agonist 2-methyl-5-hydroxytryptamine or the 5-hydroxytryptamine1-receptor agonist 5-carboxamidotryptamine.
Neuroscience  •  1992  |  View Paper
Capsaicin pretreatment of the animals resulted in rightward shifts of the dose-response curves to serotonin , 2-methyl-serotonin and TFMPP, but not to 5-methoxytryptamine or alpha-methyl-serotonin.
The Journal of pharmacology and experimental therapeutics  •  1991  |  View Paper
Capsaicin treatment after sensitization reduced the bronchial reactivity to challenge with OA aerosol and serotonin iv.
Allergy  •  1991  |  View Paper
Treatment of ovalbumin-sensitized rats with capsaicin resulted in altered bronchial reactivity to both ovalbumin and serotonin.
International archives of allergy and applied immunology  •  1989  |  View Paper
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