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Last Updated: a year ago

Possible Interaction: Capsaicin and Resiniferatoxin

supplement:

Capsaicin

Research Papers that Mention the Interaction

Capsaicin , but not CBDV, effects on burst amplitude were reversed by IRTX , a selective TRPV1 antagonist.
ACS chemical neuroscience  •  2014  |  View Paper
Lastly, the mechanisms are summarized by which capsaicin and resiniferatoxin , despite sharing receptors, may have dissimilar biological actions.
Life sciences  •  1997  |  View Paper
The discovery … as RTX , appears to give … shortcomings of capsaicin : (1) [ 3 H]RTX binding has proved the existence of the predicted vanilloid receptor and provides a promising opportunity for … the pharmacology of the receptor for the isolation of the receptor and for the detection of putative endogenous analogs. (
Advances in pharmacology  •  1993  |  View Paper
Capsaicin , anandamide, resiniferatoxin and olvanil mediated increases in [Ca2+]i were inhibited by the TRPV1 antagonists capsazepine and iodo‐resiniferatoxin with potencies (KB) of ∼70 nmol/L and 2 nmol/L, respectively.
Journal of neurochemistry  •  2007  |  View Paper
Reflex responses to epicardial bradykinin and capsaicin were mitigated by RTX.
American journal of physiology. Heart and circulatory physiology  •  2018  |  View Paper
Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 ± 18 and 76 ± 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 ± 5 and 53 ± 8% inhibitions, respectively).
European journal of pharmacology  •  2013  |  View Paper
In rat cornea, a single application of RTX dose dependently eliminated or reduced the capsaicin eye wipe response for 3–5 days, with normal nociceptive responses returning by 5–7 days.
PAIN  •  2010  |  View Paper
RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate.
Neuroscience  •  2009  |  View Paper
I-RTX , at a dose inactive per se, blocked the effect of capsaicin , and inhibited glutamate release at a higher dose.
Intra-VL-PAG injection of capsaicin increased the threshold of thermal pain sensitivity, whereas the selective TRPV1 antagonist 5′-iodo-resiniferatoxin (I-RTX) facilitated nociceptive responses, and blocked capsaicin analgesic effect at a dose inactive per se.
The Journal of Neuroscience  •  2007  |  View Paper
In rats (n = 12) pretreated with resiniferatoxin to destroy muscle afferents containing VR1, capsaicin and H+ responses were blunted.
Journal of applied physiology  •  2004  |  View Paper
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