Possible Interaction: Capsaicin and Potassium

“The number and duration of cortical spreading depressions induced by potassium were significantly increased in animals injected with capsaicin in the bilateral whisker pad compared with animals injected in the bilateral plantar or in controls, while administration of a GABAA receptor agonist decreased these effects.”

“In both species, administration of capsaicin (3·10−5 M) to the outer surface of the cell membrane reduced the amplitude and accelerated the inactivation of the fast inactivating potassium current.”

“Micromolar concentrations of capsaicin inhibited voltage-dependent sodium, calcium and potassium currents.”

“2 Capsaicin caused a time‐dependent block of both the slow and fast components of the potassium current.”

“Resiniferatoxin, capsaicin , calcitonin gene-related peptide and neurokinin A all evoked a sustained, concentration-dependent vasodilatation of potassium (60 mM)-precontracted arteries.”

“Capsaicin (1 microM) produced a similar effect, and a previous exposure to capsaicin prevented the effect of potassium.”

“ Capsaicin also induced a long-lasting relaxation of potassium and PGF2 alpha-precontracted coronary arteries.”

“ CAP attenuated the outward membrane currents with decreasing potency in the sequence of the transient potassium (IA) voltage-dependent potassium (IK), Ca-dependent potassium (IC) and leakage currents (IL).”

“We suggest that the acute action of CAP coupled with a series of events in the neuronal membrane can modify the conductance via electrically excitable calcium, potassium and sodium channels differentially.”

“Incubation with potassium (25-100 mM) produced a dose-related increase in basal CGRP-LI in the supernatant of dorsal slices which was calcium dependent and release was also evoked by incubation with capsaicin (10 microM).”