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Possible Interaction: Capsaicin and Piperine

supplement:

Capsaicin

Research Papers that Mention the Interaction

Piperine produced SIR under conditions of both self‐ and cross‐desensitization with capsaicin , whereas recovery failed to materialize with zingerone.
Pain  •  1996  |  View Paper
The concurrent addition of piperine and capsaicin seemed to inhibit synergistically the P-glycoprotein-mediated efflux.
Biological & pharmaceutical bulletin  •  2010  |  View Paper
Piperine inhibited the vagally mediated contractions in esophagi of adult mice neonatally injected with capsaicin , while capsaicin failed to do so.
European journal of pharmacology  •  2007  |  View Paper
The activity of N-demethylase essentially remained unaffected by dietary curcumin, capsaicin , or their combination, but was significantly lowered as a result of piperine feeding.
Canadian journal of physiology and pharmacology  •  2006  |  View Paper
Piperine inhibited vagally evoked contractions, while capsaicin and NG‐nitro‐L‐arginine methyl ester (L‐NAME) abolished the inhibitory effect of piperine.
The Journal of physiology  •  2003  |  View Paper
Cross-adaptation experiments revealed that capsaicin only partially desensitizes receptors for piperine , L-leucine, HCl or quinine.
Brain Research  •  1994  |  View Paper
Moreover, cross-tachyphylaxis between piperine and capsaicin was observed, suggesting that a similar mechanism may be involved in the effects of these agents.
European journal of pharmacology  •  1990  |  View Paper
Both positive chronotropic and inotropic effects of capsaicin were also attenuated after the tissue was treated with piperine or capsaicin.
However, once the tissue was pretreated with piperine or capsaicin , the response to subsequent application of piperine was reduced significantly.
Thus, not only a tachyphylaxis to either piperine or capsaicin itself but also a cross-tachyphylaxis between piperine and capsaicin developed.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper