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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Piperine produced SIR under conditions of both self‐ and cross‐desensitization with capsaicin , whereas recovery failed to materialize with zingerone.”
Rapid recovery from capsaicin desensitization during recurrent stimulation“The concurrent addition of piperine and capsaicin seemed to inhibit synergistically the P-glycoprotein-mediated efflux.”
“ Piperine inhibited the vagally mediated contractions in esophagi of adult mice neonatally injected with capsaicin , while capsaicin failed to do so.”
Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.“The activity of N-demethylase essentially remained unaffected by dietary curcumin, capsaicin , or their combination, but was significantly lowered as a result of piperine feeding.”
“Piperine inhibited vagally evoked contractions, while capsaicin and NG‐nitro‐L‐arginine methyl ester (L‐NAME) abolished the inhibitory effect of piperine.”
“Cross-adaptation experiments revealed that capsaicin only partially desensitizes receptors for piperine , L-leucine, HCl or quinine.”
“Moreover, cross-tachyphylaxis between piperine and capsaicin was observed, suggesting that a similar mechanism may be involved in the effects of these agents.”
“Both positive chronotropic and inotropic effects of capsaicin were also attenuated after the tissue was treated with piperine or capsaicin.”
“However, once the tissue was pretreated with piperine or capsaicin , the response to subsequent application of piperine was reduced significantly.”
“Thus, not only a tachyphylaxis to either piperine or capsaicin itself but also a cross-tachyphylaxis between piperine and capsaicin developed.”
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