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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Capsaicin and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

The lack of TRPV1 sensitizers, such as phosphatylinositol 4,5-bisphosphate , in the ER could contribute to decrease the affinity for capsaicin.
The Journal of Biological Chemistry  •  2009  |  View Paper
Electrophysiology experiments show that either ATP or PIP2 prevent desensitization to repeated applications of capsaicin , i.e., tachyphylaxis, while calmodulin plays an opposing role and is necessary for tachyphylaxis.
Neuron  •  2007  |  View Paper
In summary, chronic alterations in PIP2 levels regulate magnitude of CAP and MO responses as well as MO tachyphylaxis.
Journal of neuroscience research  •  2011  |  View Paper