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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“The lack of TRPV1 sensitizers, such as phosphatylinositol 4,5-bisphosphate , in the ER could contribute to decrease the affinity for capsaicin.”
The Endoplasmic Reticulum of Dorsal Root Ganglion Neurons Contains Functional TRPV1 Channels*“Electrophysiology experiments show that either ATP or PIP2 prevent desensitization to repeated applications of capsaicin , i.e., tachyphylaxis, while calmodulin plays an opposing role and is necessary for tachyphylaxis.”
“In summary, chronic alterations in PIP2 levels regulate magnitude of CAP and MO responses as well as MO tachyphylaxis.”
Chronic alteration in phosphatidylinositol 4,5‐biphosphate levels regulates capsaicin and mustard oil responses
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