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Last Updated: 2 years ago

Possible Interaction: Capsaicin and Phentolamine

supplement:

Capsaicin

Research Papers that Mention the Interaction

Significantly less MA was observed with the phentolamine infusion 10–25 min after capsaicin injection than with the saline infusion.
The Journal of Neuroscience  •  1996  |  View Paper
Conversely, intrathecal administration of an alpha-adrenoceptor antagonist, phentolamine or an opioid receptor antagonist, naloxone, to block descending antinociceptive controls, which provide inhibitory input to primary afferent nociceptors, enhanced the action of both nicotine and capsaicin.
Neuroscience  •  2004  |  View Paper
This inhibition was only slightly attenuated by 125 nmol of the alpha-adrenoceptor antagonist phentolamine or 250 nmol of the opioid receptor antagonist naloxone applied directly onto the spinal cord when the two compounds were administered separately 5 min before capsaicin.
Brain Research  •  2000  |  View Paper
Third, intra-articular perfusion with phentolamine (10(-5) M, an alpha-adrenoceptor antagonist), propranolol (10(-5) M, a beta-adrenoceptor antagonist), and naloxone (10(-5) M, an opioidergic receptor antagonist) each attenuated the inhibitory action of capsaicin.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
injection of capsaicin (30 mg kg−1) abolished the depressor reflexes in response to both types of nociceptive stimulation in phentolamine‐treated rats.
British journal of pharmacology  •  1994  |  View Paper
The inhibition by capsaicin was abolished by pre‐treatment with phentolamine or yohimbine, but was unaffected by prazosin or propranolol.
The Journal of physiology  •  1990  |  View Paper