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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Capsaicin and Phenoxybenzamine

Research Papers that Mention the Interaction

When applied after capsaicin, phenoxybenzamine inhibited thermal hyperalgesia at normal ambient temperatures, and during body warming and cooling.
When applied before capsaicin, phenoxybenzamine increased thermal hyperalgesia at normal ambient temperatures and during body warming.
European journal of pain  •  2001  |  View Paper
However, iontophoresis of phenoxybenzamine before the capsaicin treatment was ineffective.
Journal of the autonomic nervous system  •  1998  |  View Paper
The contractile response to capsaicin or neurokinin A of the rat isolated bladder were significantly reduced by incubation with phenoxybenzamine at a concentration reported to produce a selective alkylation of neurokinin-2 receptors, while the response to substance P or KCl was unaffected.
Neuroscience  •  1988  |  View Paper