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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Paclitaxel
Research Papers that Mention the Interaction
“When a mouse breast carcinoma cell line (4T1) was treated with both PTX and capsaicin ( CAP ), there was a synergistic anti-proliferative effect demonstrated with a combination index of 0.28.”
Co-delivery of paclitaxel by a capsaicin prodrug micelle facilitating for combination therapy on breast cancer.“Moreover, 24h after its injection, paclitaxel induced chemical hypersensitivity to capsaicin (a TRPV1 agonist, 0.01 nmol/site) and increased TRPV1 immunoreactivity in the dorsal root ganglion and sciatic nerve.”
Participation of transient receptor potential vanilloid 1 in paclitaxel‐induced acute visceral and peripheral nociception in rodents“When neurons … stimulated with capsaicin or AITC, a … concentration of paclitaxel (10nM) augmented transmitter release, whereas a high concentration (300 nM) reduced transmitter release in a time-dependent manner; however, … high extracellular potassium was used as the evoking stimulus, all concentrations of paclitaxel augmented CGRP release from sensory neurons.”
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