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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Capsaicin and Paclitaxel



Research Papers that Mention the Interaction

When a mouse breast carcinoma cell line (4T1) was treated with both PTX and capsaicin ( CAP ), there was a synergistic anti-proliferative effect demonstrated with a combination index of 0.28.
Molecular pharmaceutics  •  2019  |  View Paper
Moreover, 24h after its injection, paclitaxel induced chemical hypersensitivity to capsaicin (a TRPV1 agonist, 0.01 nmol/site) and increased TRPV1 immunoreactivity in the dorsal root ganglion and sciatic nerve.
European journal of pharmacology  •  2018  |  View Paper
When neurons … stimulated with capsaicin or AITC, a … concentration of paclitaxel (10nM) augmented transmitter release, whereas a high concentration (300 nM) reduced transmitter release in a time-dependent manner; however, … high extracellular potassium was used as the evoking stimulus, all concentrations of paclitaxel augmented CGRP release from sensory neurons.
Experimental Neurology  •  2014  |  View Paper