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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Novobiocin
Research Papers that Mention the Interaction
“For another, there may be another transport pathway mediating the permeation of capsaicin in M-S direction, which could be inhibited by novobiocin.”
“The permeability of capsaicin could also be inhibited unconventionally by the BCRP inhibitor novobiocin in M-S direction across colon.”
Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions.“Background and Purpose: Novobiocin (NOVO), an ABC transporter inhibitor, decreases intestinal wall permeability of capsaicin (CAP), an ABC transporter substrate.”
“In vivo data further demonstrated that oral co-administration of NOVO decreased Cmax and AUC of CAP in dosage-dependent ways, consistent with its role as a TRPV1 inhibitor.”
“Meanwhile, cytosolic accumulation of CAP decreased when NOVO was used simultaneously or 24 h in advance.”
“ NOVO down-regulated TRPV1 expression in the intestine and in transfected cells in a concentration-dependent fashion, hinting that its inhibition of the permeability of CAP is due to its inhibition of TRPV1 expression.”
“Results: In vitro data showed that there existed a dose-dependent relationship in the range of concentration between 5 and 50 μM, and even 5 μM NOVO could decrease intestinal permeability of CAP across the intestine.”
Novobiocin, a Newly Found TRPV1 Inhibitor, Attenuates the Expression of TRPV1 in Rat Intestine and Intestinal Epithelial Cell Line IEC-6
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