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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Norepinephrine
Research Papers that Mention the Interaction
“AIMS Noradrenaline increases thermal hyperalgesia in skin sensitized to heat by the topical application of capsaicin.”
“Both the noradrenaline and saline treatments inhibited thermal hyperalgesia after the topical application of capsaicin.”
“… noradrenaline heightens sensitivity to … topical application of capsaicin , and that this effect persists during arterial occlusion (Drummond, P.D., Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin, …, P.D., Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin, Pain, 67 (1996) 129-133).”
“… noradrenaline induced thermal hyperalgesia in untreated skin (mean heat pain threshold at the noradrenaline site … ± 3.5°C at control sites, P < 0.001), and increased thermal hyperalgesia in capsaicin‐treated skin (mean heat pain threshold at the noradrenaline site 38.….6°C at control sites, P < 0.001).”
Independent effects of ischaemia and noradrenaline on thermal hyperalgesia in capsaicin-treated skin“The study indicated that capsaicin may increase sympathetic function with the potentiating effects of norepinephrine.”
“These findings suggest that release of endogenous stores of noradrenaline increases sensitivity to heat in skin sensitized by capsaicin.”
“We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through α2 receptors in cultured rat dorsal root ganglion (DRG) neurons.”
Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain.“ Noradrenaline at concentrations higher than 0.1 pM significantly reduced the amplitudes of the inward capsaicin currents recorded at –60 mV holding potential.”
“The noradrenaline level in the lumbar spinal cord was significantly increased in noninjured rats receiving forepaw injection of capsaicin compared with vehicle injection (P < 0.001), but not in rats 6 weeks after SNL surgery.”
“Release of endogenous CGRP by capsaicin significantly reduced the basal overflow of NA , ir-NPY, and the electrically evoked sympathetic transmitter release.”
“Neonatal capsaicin treatment enhanced vasoconstrictor responses to norepinephrine but failed to affect escape parameters.”
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