Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Capsaicin and Nolpitantium Besilate

Research Papers that Mention the Interaction

SR140333 , at a concentration that blocked NK1‐mediated secretion (500 nM), also reduced the secretory response to both αIgE and capsaicin.
British journal of pharmacology  •  2001  |  View Paper
The increase of p-ERK1/2 after systemic capsaicin treatment was markedly attenuated by SR140333 , while only the increase in the dorsal root ganglia was impaired by SR48968; in contrast, inhibition of nitric oxide synthase had no effect.
Basic & clinical pharmacology & toxicology  •  2009  |  View Paper
Pretreatment … capsaicin partially prevented the recruitment of eosinophils after antigen challenge, suggesting the potential contribution of sensory nerves for the recruitment …–50 nmol per pleural cavity) or systemic (100–300 nmol per animal) pretreatment with the tachykinin NK1 receptor antagonist SR140333 prevented the recruitment of … challenge of immunized mice.
British journal of pharmacology  •  2003  |  View Paper
Furthermore, the capsaicin‐evoked increase in blood flow was significantly potentiated in the knockout mice (203% of wild‐type response, P<0.05) and wild‐type mice treated with SR140333 (201%, P<0.05).
British journal of pharmacology  •  2002  |  View Paper
In guinea-pig ileum, containing mainly NK1-receptors: SR140333 caused a pseudo-irreversible blockade of contractions induced … either SP (KB, 0.01 nM) or [Sar9,Met(O2)11]SP (KB, 0.03 nM); SR140333 but not SR48968, dose-dependently (IC50, 0.06 nM) antagonized the contractions elicited by capsaicin.
Life sciences  •  1995  |  View Paper