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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Nitroarginine
Research Papers that Mention the Interaction
“With the exception of the guinea-pig colon, the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine L-NOARG ; 10(-4) M) strongly inhibited the relaxant effect of capsaicin.”
Inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species.“… capsaicin (sub-maximal … synthase inhibitor NG-nitro-L-arginine (L-NOARG; 20 µM or 100 µM) or by the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-… by tetrodotoxin (1 µM) or the P2 purinoceptor antagonist pyridoxal phosphate 6-azophenyl-2',4'-disulfonic acid (PPADS; 50 µM).”
“ NG-nitro-L-arginine methyl ester (100 microM), a nitric oxide synthase inhibitor, blocked the inhibitory effect of capsaicin and exogenous application of a nitric oxide donor (1 mM) inhibited the vagally mediated twitch contractions.”
Tachykinins are involved in local reflex modulation of vagally mediated striated muscle contractions in the rat esophagus via tachykinin NK1 receptors“After treatment with L-NNA and after acute and chronic administration of capsaicin , the bile-oleate-induced maximal increases in BF above control levels were 42±7%, 65±12%, and 58±8%, respectively.”
“ L-NNA (10(-4) M) completely inhibited the effects of ACh and capsaicin on the Kf,c, without preventing the effects of SP and 5-HT.”
“In normal fed and refed rats, the neurotoxic dose of capsaicin together with L-NNA significantly decreased the DNA synthesis, stomach weight, RNA and DNA content but these effects were smaller than the sum of the effects of each agent given alone.”
“The combination of capsaicin and L-NNA decreased the MBF significantly and the inhibition was stronger than the effect of each substance given alone.”
“The neurogenic vasoconstriction of mesenteric arteries was also augmented by capsaicin , but to a lesser extent than that induced by Nω‐nitro‐l‐arginine.”
“Moreover, pretreating the cells with the nitric oxide synthase inhibitor, NG-nitro-L-arginine (100 microM), abolished the rise in cyclic guanosine 3',5'-monophosphate induced by capsaicin without altering capsaicin-stimulated release of either peptide.(ABSTRACT TRUNCATED AT 250 WORDS)”
“Combined incubation with capsaicin and L-NOARG nearly abolished the NANC response.”
“Treatment with capsaicin reduced the NANC response by 16 +/- 2% (P < 0.001) and inhibition of the NO synthase with 1 x 10(-4) M L-NOARG reduced the NANC response by 83 +/- 10% (P < 0.001).”
“The NO synthase inhibitor, NG-nitro-L-arginine (L-NNA), significantly inhibited basal gastroduodenal alkaline secretion and almost completely suppressed the alkaline responses to food, acid or capsaicin.”
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