Possible Interaction: Capsaicin and Nitric Oxide

“Conversely, when on capsaicin, NO significantly increased at 6 hours.”

“It is concluded that nitric oxide , possibly of sensory origin, is involved in the relaxant action of capsaicin in the circular muscle of the mouse and human intestine.”

“ Capsaicin potently inhibits tone and movements of human intestinal preparations, an effect mediated by nitric oxide ( NO ) and/or vasoactive intestinal polypeptide.”

“Significant increase in NO release was observed when cells were incubated with CEX (100 microg/mL) and CAP (25 microM) and this effect was inhibited by CZP only in CAP treatment group.”

“ Nitric oxide decreased by capsaicin or capsaicin/phenytoin.”

“In addition, R-methanandamide and capsaicin (0.01 μM), a TRPV1 agonist, increased NO production via the PKA pathway.”

“ Capsaicin decreased MDA (-45.5-76.1%), ET-1 (-19.6-51.6%), and average gray value (AGV) of eNOS (-10.9-48.8%), and increased SOD activity (+31.7-76.1%), NO (+11.2-36.8%), and AGV of iNOS (+6.8-+93.0%) (all P < 0.05).”

“Phospho-eNOS levels were augmented, and NO production increased following the administration of capsaicin.”

“ CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.”

“Using 4,5-diaminofluorescein diacetate for nitric oxide (NO) imaging, we found that capsaicin also increased the production of NO in retinal blood vessels.”