Possible Interaction: Capsaicin and Nicotine

“We hypothesized that withdrawal from and administration of nicotine in smoking subjects would modulate their anxiety levels, urge-to-cough and cough motor response to capsaicin stimulation.”

“Furthermore, nicotine evoked a significantly weaker sensation on the side of the tongue pretreated with capsaicin (cross-desensitization).”

“… capsaicin … nicotine ; 2) when the central end of the left cardiac sympathetic nerve was electrically stimulated, both the pressor and the RSNA responses to chemoreflex activation …) bilateral microinjection of losartan (250 pmol) into the nucleus tractus solitarii (NTS) completely abolished the enhanced chemoreceptor reflex by epicardial application of capsaicin.”

“The response to nicotine was also reduced following local pretreatment with capsaicin , while the response to systemic pretreatment with capsaicin was only slightly affected.”

“Also, neonatal treatment with capsaicin , a procedure that is associated with a selective degeneration of primary sensory C-fibre afferents, clearly antagonized the effect of nicotine on LC neurons.”

“The responses to nicotine were of short duration and blocked in preparations pre‐treated for 10 min with capsaicin (1 μM) and are therefore probably a consequence of the stimulation of trigeminal C fibre terminals.”

“The release of CGRP evoked by capsaicin was also reduced after nicotine and cytisine desensitization.”

“The relaxation produced by nicotine was attenuated in the presence of capsaicin (3 x 10(-7) M) to desensitize sensory nerves.”

“Pretreatment with 3 mM capsaicin applied locally to the nasal mucosa abolished or reduced the vasodilation in response to capsaicin, nicotine , and ammonia vapor but not to light mechanical or electrical stimulation of the nasal mucosa.”

“Perfusion of control rat adrenal glands with capsaicin did not evoke CA secretion, but did increase CA secretion in response to perfusion with nicotine.”