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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
Research Papers that Mention the Interaction
“With the exception of the guinea-pig colon, the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine (L-NOARG; 10(-4) M) strongly inhibited the relaxant effect of capsaicin.”
Inhibition of nitric oxide synthesis blocks the inhibitory response to capsaicin in intestinal circular muscle preparations from different species.“Pretreatment with either L-NAME (3 X10(-4) mol/L), an inhibitor of nitric oxide synthase(NOS), or CGRP8-37 (2 X 10(-6) mol/L), an antagonist of calcitonin gene-related peptide (CGRP), for 30 min significantly attenuated the relaxation of endothelium-intact mesenteric artery induced by CAP.”
[Vasodilating effect of capsaicin on rat mesenteric artery and its mechanism].“ Capsaicin (1-100 μg·kg(-1)·min(-1)) dose dependently increased coronary blood flow in control mice, which was inhibited by the TRPV1 antagonist capsazepine or the nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (L-NAME).”
“Pretreatment with indomethacin reduced the protective effects of piperine, and L-NAME reduced the effects of capsaicin and omeprazole.”
“Additionally, a tachykinin NK(1) receptor antagonist, L-732,138 (1 microM), as well as a nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME 200 microM), blocked the inhibitory effect of capsaicin but not that of piperine.”
“Comparison of the graded dose-effect curves for capsaicin alone and capsaicin plus L-NAME revealed a significant difference (P<0.05), thus indicating synergy for the drug interaction.”
“The super-additive hypothermia produced by the concurrent administration of capsaicin and L-NAME (50mg/kg, i.p.)”
“Luminal … of capsaicin increased the secretion of HCO3− in a dose-dependent manner; this effect was markedly attenuated by chemical ablation of …-sensitive afferent neurons (CSN) as well as pretreatment with ruthenium red or capsazepine, and significantly mitigated by indomethacin or l-NAME (in an l-arginine-sensitive manner).”
“Mucosal application of capsaicin as well as acid increased the mucosal PGE2 content, and these effects were both significantly attenuated by indomethacin and l-NAME.”
“These effects induced by capsaicin and CGRP were inhibited by pretreatment with L-NAME and indomethacin but not by pretreatment with AG and NS-398.”
“Both lafutidine and capsaicin significantly increased intestinal mucus secretion, and these effects were also attenuated by prior administration of L-NAME.”
“However, L-NAME induced duodenal contractions that were augmented by capsaicin , ethanol and HCl, but not by CO2.”
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