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Possible Interaction: Capsaicin and Nerve Growth Factor

Research Papers that Mention the Interaction

In situ hybridization histochemistry (ISH) … at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small … cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase … GAP-43 expression in the small-sized cell population.
Regulatory Peptides  •  1999  |  View Paper
NGF acutely conditions the response to capsaicin , suggesting that NGF may be important in sensitizing the response of sensory neurons to heat (a process that is thought to operate via the capsaicin receptor VR1).
Proceedings of the National Academy of Sciences of the United States of America  •  1999  |  View Paper
CAPS tachyphylaxis lowered signal intensity by ~60% but was largely prevented by NGF.
Increasing CAPS from 1 to 10 μM nearly doubled the number of cells activated but only modestly increased the amount co-activated by NGF.
NGF elevated [Ca2+]i in about one-third of the neurons stimulated by 1 μM CAPS , whether applied before or after the latter.
International journal of molecular sciences  •  2021  |  View Paper
NGF increased capsaicin current amplitude from 144 (42) to 840 (132) pA (P<0.05), which was blocked by the TRPV1 antagonist 5'-iodoresiniferatoxin.
British journal of anaesthesia  •  2019  |  View Paper
We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are … in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased … number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).
Neuroscience  •  2014  |  View Paper
The ocular effects of capsaicin treatment were associated with an NGF pathway alteration.
Investigative ophthalmology & visual science  •  2012  |  View Paper
The elevation of SP mRNA, VR1 mRNA, and VR1 protein promoted by NGF and/or butyrate may be associated with increases of SP release evoked by capsaicin.
Acta physiologica Hungarica  •  2009  |  View Paper
Furthermore, when NGF was infused in the hindlimb muscles of healthy rats (72 h using an osmotic minipump), the magnitude of the DRG neuron response to capsaicin was augmented (5.4 +/- 0.54 nA with NGF infusion vs. 3.0 +/- 0.17 nA in control; P < 0.05).
With the addition of NGF in the culture dish containing the DRG neurons, the magnitude of the DRG neuron response to capsaicin was greater (6.4 +/- 0.27 nA; P < 0.05 vs. control) than that seen in control (2.9 +/- 0.16 nA).
American journal of physiology. Heart and circulatory physiology  •  2009  |  View Paper
The present study demonstrates that a capsaicin impairment of small diameter primary sensory neurons followed by an NGF treatment evokes a characteristic pattern of ERK and STAT3 activation indicative of neuronal degeneration and regeneration.
intraplantar nerve growth factor (NGF) injection at … h after the capsaicin treatment, and collection of tissues 4 h later, markedly increased the level of phospho-ERK in the sciatic nerve … DRG, as compared to the samples taken from rats at the same time points with a capsaicin treatment only.
Pharmacology  •  2005  |  View Paper
The results show that topical administration of capsaicin causes a primarily NK1 receptor‐dependent increase in the NGF content of rat skin, which is susceptible to inhibition by beta adrenergic agonists.
Topical capsaicin (>1 mg/ml ethanol) caused a concentration‐ and time‐dependent increase in the concentration of NGF in rat skin.
Pain  •  2004  |  View Paper
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