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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The increase of firing frequency produced by capsaicin and dihydrocapsaicin was inhibited by morphine and this inhibition was antagonized by naloxone.”
Excitatory effects of dihydrocapsaicin on nociceptive neurons in the medial thalamus.“Treatment with naloxone (0.5 nmol/eye) almost completely negated the protective effects of capsaicin , CGRP, &bgr;‐endorphin, and substance P in the NMDA‐injected rats.”
Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina“Conversely, intrathecal administration of an alpha-adrenoceptor antagonist, phentolamine or an opioid receptor antagonist, naloxone , to block descending antinociceptive controls, which provide inhibitory input to primary afferent nociceptors, enhanced the action of both nicotine and capsaicin.”
“Third, intra-articular perfusion with phentolamine (10(-5) M, an alpha-adrenoceptor antagonist), propranolol (10(-5) M, a beta-adrenoceptor antagonist), and naloxone (10(-5) M, an opioidergic receptor antagonist) each attenuated the inhibitory action of capsaicin.”
“Contractions of similar size evoked by capsaicin (0.3 microM) in the presence of naloxone were abolished by capsaicin pretreatment, reduced by substance P desensitization or hyoscine but not by desensitization to serotonin.”
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