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Last Updated: a year ago

Possible Interaction: Capsaicin and Morphine

supplement:

Capsaicin

Research Papers that Mention the Interaction

Morphine use from 12-24 hours was lower ( capsaicin group mean 13.4 mg; 95% confidence interval [CI] 7.4, 19.5; range 10-21 mg vs placebo group mean 25.9 mg; 95% CI 19.8, 32.0; range 15-36 mg; p = 0.009).
Total intravenous and oral opioid in morphine equivalents over 72 hours was also lower with capsaicin compared with placebo (p = 0.03).
Clinical drug investigation  •  2011  |  View Paper
Additional factors also include capsaicin treatment blocking the anti-nociception effects of morphine in rats, as well as opioid modulation of TRPV1 responses through the cAMP-dependent PKA pathway and MAPK signaling pathways.
Channels  •  2015  |  View Paper
The increase of firing frequency produced by capsaicin and dihydrocapsaicin was inhibited by morphine and this inhibition was antagonized by naloxone.
Japanese journal of pharmacology  •  1980  |  View Paper
Compared with active placebo diphenhydramine (50 mg oral dose), pregabalin and morphine significantly reduced the area of secondary hyperalgesia over 15 to 240 minutes after capsaicin injection (approximately 25%, P = .002 and approximately 33%, P < .001, respectively).
The journal of pain : official journal of the American Pain Society  •  2008  |  View Paper
ResultsIn the present studies we investigated the hypothesis that the μ opioid receptor (MOP) agonist morphine can modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway.
Molecular pain  •  2006  |  View Paper
Morphine reduced pain produced by capsaicin (presumed to selectively excite unmyelinated peripheral afferents) but did not diminish pain elicited by bradykinin (presumed to excite A&dgr; and C nociceptors).
Pain  •  1986  |  View Paper
The data showed that the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) and the amplitudes of evoked excitatory postsynaptic currents (eEPSCs) were increased during morphine withdrawal after applied with capsaicin (TRPV1 agonist).
Brain Research  •  2017  |  View Paper
CARV, CARV-βCD and Morphine (MOR) showed a significant reduction against nociception caused by capsaicin or glutamate injection.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2016  |  View Paper
As long as morphine did not cause reduced participation due to sedation, subcutaneous morphine dosing reduced the effects of capsaicin (p<0.001).
Journal of Neuroscience Methods  •  2015  |  View Paper
It was shown previously (J …:6747–6755, 2002) that sustained morphine exposure augments pain neurotransmitter [such as calcitonin gene-related peptide (CGRP)] release in the dorsal horn of the spinal … response to the heat-sensing transient receptor potential vanilloid 1 receptor agonist 8-methyl-N-vanillyl-6-nonenamide ( capsaicin).
Journal of Pharmacology and Experimental Therapeutics  •  2009  |  View Paper
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