Possible Interaction: Capsaicin and Lidocaine

“ Lidocaine and prilocaine alone (e.g., at 10 mM) significantly increased [Ca2+]i by 67 ± 6 nM and 33 ± 7 nM, respectively, and concentration-dependently inhibited the capsaicin response.”

“Laryngopharngeal anesthesia with lidocaine dramatically increased C5 to capsaicin in the subjects of all 3 groups by a similar degree, but the increase in the UACS group was still the lowest, with an increased level of histamine, PGE2, and CGRP in the induced sputum.”

“Lignocaine (40 mg) and dyclonine (8 mg) caused significant reports of oral anaesthesia but only lignocaine reduced the cough response to inhaled capsaicin , increasing the log dose of capsaicin causing three or more coughs by 162%.”

“Results: N-Methyl amitriptyline, amitriptyline, bupivacaine, or lidocaine , followed by injection of capsaicin 10 min later, each elicited a predominantly nociceptive-specific blockade.”

“Pretreatment with lidocaine , the β-receptor agonist, terbutaline, or the adenosine non-blocking xanthine, enprofylline, inhibited the capsaicine induced inflammatory response.”

“ Lidocaine injections (50 mg) into the pulmonary artery of the vascularly isolated lung abolished all reflex responses to subsequent injections of capsaicin , but only attenuated the triad of responses to subsequent left lung inflations by half.”

“Pre-treatment with epicardial application of lidocaine to the anterior wall abolished the CSAR evoked by application of BK or capsaicin but had no effects on the CSAR evoked by epicardial application of BK or capsaicin to the posterior wall.”

“Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment.”

“Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR.”

“These results suggest that capsaicin may be a useful agent for the reversible potentiation of phasic impulse blockade by lidocaine.”

“These results suggest that capsaicin may be a useful agent for the potentiation of impulse blockade by lidocaine.”