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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Capsaicin
drug:
Lafutidine
Research Papers that Mention the Interaction
“Additionally, the protective effect of lafutidine , but not of famotidine, was partly attenuated by the denervation of capsaicin-sensitive afferent nerves with a large dose of capsaicin.”
Possible Involvement of Host Defense Mechanism in the Suppression of Rat Acute Reflux Esophagitis by the Particular Histamine H2 Receptor Antagonist Lafutidine“Stimulation of the capsaicin pathway with compounds such as Laf enhances mucosal protection from acid-related injury in the upper gastrointestinal tract.”
“Perfusion of lafutidine concentration-dependently augmented vasodilation induced by a bolus injection of capsaicin (vanilloid-1 receptor agonist, 30 pmol).”
“In conclusion, our findings demonstrate that lafutidine modulates the activity of capsaicin sensitive afferent nerves in the rat stomach, which may be a key mechanism involved in its gastroprotective action.”
“ Lafutidine enhanced both CGRP and NO release from the rat stomach induced by a submaximal dose of capsaicin , but had no effect on specific [3H]‐RTX and capsaicin binding to VR1.”
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