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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ObjectiveThe predelivery of intravenous alfentanil (a &mgr; opioid agonist) and ketamine (an N-methyl d-aspartate antagonist) has recently been shown to decrease the secondary hyperalgesia induced by intradermal capsaicin.”
Postdelivery of Alfentanil and Ketamine Has No Effect on Intradermal Capsaicin–Induced Pain and Hyperalgesia“Intraplantar administration of ketamine caused an unexpected increase in nocifensive behavior induced by capsaicin.”
“ Ketamine also prevented TRPV1 receptor desensitization induced by successive applications of capsaicin.”
“Taken together, our data indicate that ketamine potentiates TRPV1 receptor sensitivity to capsaicin through a mechanism dependent on PKCє activity.”
“Subanaesthetic doses of ketamine specifically reduce primary and secondary hyperalgesia after capsaicin or burn injury (9-11), and also reduce temporal summation of pain (8,12) and postoperative hyperalgesia (13).”
“Intranasal ketamine also reduced the facial heat hyperalgesia induced by capsaicin and carrageenan.”
Analgesic Effects of Intranasal Ketamine in Rat Models of Facial Pain.
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