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Last Updated: a year ago

Possible Interaction: Capsaicin and Indomethacin

supplement:

Capsaicin

Research Papers that Mention the Interaction

The effects were attenuated by both the ablation of CSN and pretreatment with N(G)-nitro-L-arginine methyl ester, yet only the effect of capsaicin was mitigated by prior administration of capsazepine, the TRPV1 antagonist, as well as indomethacin.
World journal of gastroenterology  •  2006  |  View Paper
Capsaicin induced dose-dependent relaxation responses in carbachol-…,060) [neurokinin 1 (NK1) receptor antagonist], indomethacin [cyclooxygenase (COX) inhibitor], and the combination of 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH6809) and 7-[…), activation of epithelial NK1 receptors, and production of COX products capable of activating relaxant EP2/EP4 receptors.
Journal of Pharmacology and Experimental Therapeutics  •  2012  |  View Paper
Prostaglandin synthase inhibitor indomethacin ; 10 mg/kg) blocked the venom-induced augmentation of PBG and capsaicin reflexes.
Pulmonary pharmacology & therapeutics  •  2012  |  View Paper
Pretreatment with indomethacin reduced the protective effects of piperine, and L-NAME reduced the effects of capsaicin and omeprazole.
European journal of pharmacology  •  2007  |  View Paper
In the presence of neurotoxic doses of capsaicin, the negative influence of capsaicin on restraint, ethanol, or indomethacin lesions consistently affected salutary activity of BPC 157.
Digestive Diseases and Sciences  •  2005  |  View Paper
On the other hand, the mucosal application of capsaicin (0.3–6 mg/ml) increased the luminal pH and HCO3− output in a concentration-related manner, and this action was also significantly attenuated by either indomethacin or chemical deafferentation of capsaicin-sensitive sensory neurons.
Digestive Diseases and Sciences  •  2005  |  View Paper
Macroscopic lesions appeared only in ethanol and indomethacin gastritis and were enhanced by capsaicin treatment.
Autonomic Neuroscience  •  2004  |  View Paper
Luminal … of capsaicin increased the secretion of HCO3− in a dose-dependent manner; this effect was markedly attenuated by chemical ablation … capsaicin-sensitive afferent neurons (CSN) as well as pretreatment with ruthenium red or capsazepine, and significantly mitigated by indomethacin or l-NAME (in an l-arginine-sensitive manner).
Mucosal application of capsaicin as well as acid increased the mucosal PGE2 content, and these effects were both significantly attenuated by indomethacin and l-NAME.
Digestive Diseases and Sciences  •  2004  |  View Paper
These effects induced by capsaicin and CGRP were inhibited by pretreatment with L-NAME and indomethacin but not by pretreatment with AG and NS-398.
American journal of physiology. Gastrointestinal and liver physiology  •  2003  |  View Paper
Indomethacin also inhibited the protective action of capsaicin , and this was accompanied by reduced levels of intragastric CGRP.
Gut  •  2003  |  View Paper
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