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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Indomethacin
Research Papers that Mention the Interaction
“The effects were attenuated by both the ablation of CSN and pretreatment with N(G)-nitro-L-arginine methyl ester, yet only the effect of capsaicin was mitigated by prior administration of capsazepine, the TRPV1 antagonist, as well as indomethacin.”
Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.“ Capsaicin induced dose-dependent relaxation responses in carbachol-…,060) [neurokinin 1 (NK1) receptor antagonist], indomethacin [cyclooxygenase (COX) inhibitor], and the combination of 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH6809) and 7-[…), activation of epithelial NK1 receptors, and production of COX products capable of activating relaxant EP2/EP4 receptors.”
Influence of Influenza A Infection on Capsaicin-Induced Responses in Murine Airways“Prostaglandin synthase inhibitor indomethacin ; 10 mg/kg) blocked the venom-induced augmentation of PBG and capsaicin reflexes.”
“Pretreatment with indomethacin reduced the protective effects of piperine, and L-NAME reduced the effects of capsaicin and omeprazole.”
“In the presence of neurotoxic doses of capsaicin, the negative influence of capsaicin on restraint, ethanol, or indomethacin lesions consistently affected salutary activity of BPC 157.”
“On the other hand, the mucosal application of capsaicin (0.3–6 mg/ml) increased the luminal pH and HCO3− output in a concentration-related manner, and this action was also significantly attenuated by either indomethacin or chemical deafferentation of capsaicin-sensitive sensory neurons.”
“Macroscopic lesions appeared only in ethanol and indomethacin gastritis and were enhanced by capsaicin treatment.”
“Luminal … of capsaicin increased the secretion of HCO3− in a dose-dependent manner; this effect was markedly attenuated by chemical ablation … capsaicin-sensitive afferent neurons (CSN) as well as pretreatment with ruthenium red or capsazepine, and significantly mitigated by indomethacin or l-NAME (in an l-arginine-sensitive manner).”
“Mucosal application of capsaicin as well as acid increased the mucosal PGE2 content, and these effects were both significantly attenuated by indomethacin and l-NAME.”
“These effects induced by capsaicin and CGRP were inhibited by pretreatment with L-NAME and indomethacin but not by pretreatment with AG and NS-398.”
“ Indomethacin also inhibited the protective action of capsaicin , and this was accompanied by reduced levels of intragastric CGRP.”
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