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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ABSTRACT Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin‐sensitive.”
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage“After 60 min of capsaicin treatment, both the perfusion and interstitial concentration of histamine , as well as the net release of histamine, were significantly increased in affected (from 38 ± 6 to 45 ± 6 nmol/L, mean ± SEM) and unaffected (from 15 ± 2 to 19 ± 2 nmol/L) skin.”
“ Capsaicin pre‐treatment caused significant inhibition of the immediate mean flare responses (95% CI) to both bradykinin (….7–63.3] mm2 to 16.2 [8.0–24.5] mm2) (P < 0.01) and histamine (from 108.4 [80.4–136.4] mm2 ….1–67.1] mm2) (P < 0.01).”
“Topical capsaicin elicited a significant inhibition of the weal response induced by histamine , the mean weal area being reduced from 14.8 (12.6–17.0) mm2 to 12.1 (10.1–14.1) mm2 (P < 0.05).”
“However, the area of flare produced by histamine was significantly reduced in capsaicin‐treated skin.”
“The topical capsaicin robustly, and with similar efficaciousness, inhibited itch intensity evoked by electrical stimulation and histamine (-89±4.1% and -78±4.9%, respectively, both: P<0.0001 compared to the placebo patch area).”
“Pretreatment of the skin with capsaicin (1% alcoholic solution) for 2 or 3 days markedly reduced the histamine- or substance P-induced blood flow increase.”
“ Capsaicin pretreatment caused significant inhibition … flare response to histamine in both normal (19.8 +/- 2.6 to 7.3 +/- 2.9 cm2 at 5 minutes; p less than 0.… atopic subjects (16.5 +/- 1.4 to 10.3 +/- 1.9 cm2 at 5 minutes; p less than 0.01).”
“The flare response to SP and histamine was suppressed by capsaicin pretreatment whereas the wheal was enlarged.”
“Pre‐treatment of the skin with capsaicin reduced the flare but not the wheal response to intradermal injection of histamine.”
“ Capsaicin treatment potentiated responses of trachea and bronchus on the effect of histamine induced preganglionic stimulation by 12-14%.”
[Role intramural ganglion airway on action of histamine].
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