Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Capsaicin and Histamine



Research Papers that Mention the Interaction

ABSTRACT Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin‐sensitive.
PAIN®  •  2009  |  View Paper
After 60 min of capsaicin treatment, both the perfusion and interstitial concentration of histamine , as well as the net release of histamine, were significantly increased in affected (from 38 ± 6 to 45 ± 6 nmol/L, mean ± SEM) and unaffected (from 15 ± 2 to 19 ± 2 nmol/L) skin.
The British journal of dermatology  •  1999  |  View Paper
Capsaicin pre‐treatment caused significant inhibition of the immediate mean flare responses (95% CI) to both bradykinin (….7–63.3] mm2 to 16.2 [8.0–24.5] mm2) (P < 0.01) and histamine (from 108.4 [80.4–136.4] mm2 ….1–67.1] mm2) (P < 0.01).
Topical capsaicin elicited a significant inhibition of the weal response induced by histamine , the mean weal area being reduced from 14.8 (12.6–17.0) mm2 to 12.1 (10.1–14.1) mm2 (P < 0.05).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology  •  1992  |  View Paper
However, the area of flare produced by histamine was significantly reduced in capsaicin‐treated skin.
Pain  •  1991  |  View Paper
The topical capsaicin robustly, and with similar efficaciousness, inhibited itch intensity evoked by electrical stimulation and histamine (-89±4.1% and -78±4.9%, respectively, both: P<0.0001 compared to the placebo patch area).
Neuroscience Letters  •  2018  |  View Paper
Pretreatment of the skin with capsaicin (1% alcoholic solution) for 2 or 3 days markedly reduced the histamine- or substance P-induced blood flow increase.
The Japanese journal of physiology  •  1991  |  View Paper
Capsaicin pretreatment caused significant inhibition … flare response to histamine in both normal (19.8 +/- 2.6 to 7.3 +/- 2.9 cm2 at 5 minutes; p less than 0.… atopic subjects (16.5 +/- 1.4 to 10.3 +/- 1.9 cm2 at 5 minutes; p less than 0.01).
The Journal of allergy and clinical immunology  •  1989  |  View Paper
The flare response to SP and histamine was suppressed by capsaicin pretreatment whereas the wheal was enlarged.
Acta dermato-venereologica  •  1986  |  View Paper
Pre‐treatment of the skin with capsaicin reduced the flare but not the wheal response to intradermal injection of histamine.
The Journal of physiology  •  1983  |  View Paper
Capsaicin treatment potentiated responses of trachea and bronchus on the effect of histamine induced preganglionic stimulation by 12-14%.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova  •  2014  |  View Paper
Show More