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Possible Interaction: Capsaicin and Hexamethonium

supplement:

Capsaicin

Research Papers that Mention the Interaction

capsaicin … hexamethonium (1×10−4 g/ml).5.Unaltered contractions were produced by capsaicin on ileal segments made tachyphylactic to 5-HT, bradykinin or substance P. ….6.It is concluded that in the guinea-pig ileum capsaicin causes predominantly cholinergic contraction by stimulating terminals of extrinsic, non-parasympathetic nerves.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The bronchodilation induced by capsaicin was significantly suppressed by hexamethonium and by L-NAME.
The European respiratory journal  •  1999  |  View Paper
The excitatory effect of capsaicin on colonic motility was inhibited by atropine and hexamethonium.
Gastroenterology  •  1995  |  View Paper
A ganglionic-blocking dose (10 mg/kg) of intraperitoneal hexamethonium also significantly attenuates the gastric vasodilatory effect of intragastric capsaicin.
The American journal of physiology  •  1993  |  View Paper
Hexamethonium increased both Ch and the duration of RH and tended to reverse reductions in these parameters caused by capsaicin.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1992  |  View Paper
Ruthenium red (3-5 microM) antagonism of the inhibitory effect of capsaicin (1 microM) on the contractile response to mesenteric nerve stimulation in the presence of hexamethonium (50 microM) and guanethidine (2 microM) was reversed significantly by sialic acid (2 mM) or neuraminidase (0.1 U/ml).
European journal of pharmacology  •  1992  |  View Paper
The secretory response to capsaicin (80 nmol/kg ia) was completely blocked by atropine and hexamethonium , indicating that a cholinergic reflex mediates capsaicin-induced nasal hypersecretion in this model.
Journal of applied physiology  •  1991  |  View Paper
Hexamethonium (0.7-1.2 mg/kg iv) prevented C-fiber stimulation by high-nicotine cigarette smoke (n = 12) but not stimulation by right atrial injection of capsaicin.
Journal of applied physiology  •  1989  |  View Paper
These responses were inhibited totally or mostly by capsaicin , administered neonatally, topically, or perineurally, by topical lidocaine, and by parenteral administration of substance P antiserum, somatostatin, or hexamethonium.
Gastroenterology  •  1988  |  View Paper