Possible Interaction: Capsaicin and Glucose

“The plasma level of glucose increased significantly from 30 to 150 min, and the plasma glucagon level increased from 90 to 180 min after the glucose loading when capsaicin administered.”

“The fact that capsaicin interfered only with the adrenal effect of insulin suggests the involvement of afferent C-… in this insulin effect.6.Injection into the hepatic portal vein of a C-fibre stimulating dose of capsaicin … arterial glucose concentrations in vehicle-pretreated rats … not in capsaicin-pretreated rats.”

“The 15 mg/kg dose of capsaicin significantly (p < 0.05) enhanced the endurance performance time and plasma concentration of epinephrine, norepinephrine, free fatty acid and glucose rose to significantly higher levels within 30 min; swimming exercise compared to rest (p < 0.05).”

“ Capsaicin stimulation of afferent neurones increased hyperglycaemic responses to glucose and decreased hypoglycaemia in control rats.”

“One to 7 days after perfusion of the intestine with capsaicin (3.6 mumol), feedback inhibition of gastric emptying produced by acid, glucose , or lipid was inhibited 100, 59, and 42%, respectively.”

“Absorption of water, glucose and alanine was found to be significantly reduced in the presence of capsaicin.”

“ Capsaicin treatment partially reduced the glucose and glucagon responses to 2-DG (P less than 0.01).”

“Similarly, dietary capsaicin resulted in remarkable improvement in glucose and insulin tolerance.”