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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Capsaicin and Formalin



Research Papers that Mention the Interaction

Pretreatment with capsaicin , a neurotoxin selective for unmyelinated small diameter primary afferent nerves, markedly reduced the adenosine released by 1.5% formalin and the early phase of release by 5% formalin.
European journal of pharmacology  •  2001  |  View Paper
5 Desensitization of small diameter sensory neurones with a single subplantar injection of capsaicin (100 μg) abolished all behaviours indicative of spontaneous nociceptive sensation in animals subsequently injected with α,β‐methylene ATP (600 nmol), bradykinin (1 nmol) or formalin (0.5%, 0.1 ml).
British journal of pharmacology  •  1997  |  View Paper
Paw swelling, flinching and release of spinal prostaglandin E2 induced by injection of formalin into the hindpaw were also reduced in capsaicin-treated rats compared with controls, whereas glutamate, aspartate and taurine release was unaffected.
Neuroreport  •  1997  |  View Paper
The capsaicin treatment markedly reduced the sensitivity of formalin test pain to morphine.
Pain  •  1985  |  View Paper
The inflammation produced by an injection of formalin to the plantar surface of the hind paw was reduced equally by capsaicin or capsaicin + guanethidine.
Neuroscience Letters  •  1984  |  View Paper
2 In rats pretreated … of 50 mg capsaicin over 4 … to capsaicin, formalin , HCl, KCl, prostaglandin E1, bradykinin and bradykinin with prostaglandin E1 (10−6 m) were greatly reduced, the responses … 5‐hydroxytryptamine were slightly reduced and those to adenosine 5′‐triphosphate (ATP) and compound 48/80 were unaffected.
British journal of pharmacology  •  1977  |  View Paper