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Last Updated: 4 months ago

Possible Interaction: Capsaicin and Folic Acid Antagonists

Research Papers that Mention the Interaction

The … antagonist (36) exhibited potent and selective … hTRPV1 not only to capsaicin but also to NADA and elevated temperature; however, it only displayed weak antagonism to low pH. Further studies indicated … administration of antagonist 36 blocked the hypothermic effect of capsaicin in vivo but demonstrated hyperthermia at that dose.
Bioorganic & medicinal chemistry  •  2018  |  View Paper
Both compounds also proved to be very potent antagonists for rTRPV1, blocking in vivo the hypothermic action of capsaicin , consistent with their in vitro mechanism.
Bioorganic & medicinal chemistry letters  •  2017  |  View Paper
Nonetheless, antagonists retain protective efficacy against capsaicin toxicity when added several minutes after capsaicin , conditions in which the cells still manifest elevated intracellular sodium, but not elevated intracellular calcium.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
By contrast, the CB(1) receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca(2+) concentration, although at concentrations higher than those required for CB(1) antagonism.
The Journal of biological chemistry  •  2001  |  View Paper
At micro- to millimolar concentrations, commonly used in clinical and in vitro studies, capsaicin also modulates the function of a large number of seemingly unrelated membrane proteins, many of which are similarly modulated by the capsaicin antagonist capsazepine.
Molecular pharmacology  •  2005  |  View Paper
Further studies demonstrated that antagonist 6 blocked the hypothermic effect of capsaicin in vivo, consistent with its in vitro mechanism, and it showed promising analgesic activity in the formalin animal model.
Bioorganic & medicinal chemistry letters  •  2018  |  View Paper
Capsaicin evoked slow EPSP-like responses that were suppressed by antagonists for protease-activated receptor 2.
American journal of physiology. Gastrointestinal and liver physiology  •  2014  |  View Paper
In the presence of this antagonist, capsaicin induced a short-living and (+/-)-CP 96,345-sensitive twitch enhancement.
European journal of pharmacology  •  1995  |  View Paper
With both antagonists , the CAP effect was completely blocked, and the NADA effect was partially blocked.
The Journal of Membrane Biology  •  2014  |  View Paper
We showed previously that injection of NK-1 receptor antagonists into the RVM attenuated mechanical and heat hyperalgesia produced by intraplantar injection of capsaicin.
Journal of neurophysiology  •  2012  |  View Paper
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