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Last Updated: a year ago

Possible Interaction: Capsaicin and Fluorouracil

supplement:

Capsaicin

Research Papers that Mention the Interaction

Further investigation revealed that the autophagy induced by 5-FU was inhibited by capsaicin.
In addition, the combination of capsaicin with 5-FU was synergistic, with a combination index (CI) < 1, and the combined treatment also suppressed tumor growth in the CCA xenograft to a greater extent than 5-FU alone.
Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin , indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.
The drug sensitivity of QBC939 to 5-FU was significantly enhanced by capsaicin compared with either agent alone.
PloS one  •  2015  |  View Paper
Results suggested that capsaicin had significant anticancer abilities; such capsaicin were capable of causing multifold decreases in the half maximal inhibitory concentration IC50 value of 5-FU.
Tumor Biology  •  2014  |  View Paper