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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Epoprostenol
Research Papers that Mention the Interaction
“Taken together these data suggest that prostacyclin may have a facilitory role in the micturition reflex by modulating the threshold for activation of capsaicin sensitive and insensitive bladder sensory afferents.”
Effects of the selective prostacyclin receptor antagonist RO3244019 on the micturition reflex in rats.“Intragastric application of capsaicin increased mucosal PGI2 but not PGE2 levels in the rat stomach.”
“Conclusions: The present results suggest that endogenous prostaglandin I2 enhances the protective action of the capsaicin mediated neural emergency system against ethanol induced gastric mucosal injury through enhancement of CGRP release.”
“In the present study, we tested whether endogenous prostaglandin I2 also modulates the cytoprotective action of capsaicin using prostaglandin I receptor knockout mice (IP−/−).”
“ capsaicin in small doses nor local capsaicin desensitization modify the mucosal cytoprotective effects of prostacyclin.”
“One nM CPGI2 , a concentration that did not alter the resting release, significantly enhanced neuropeptide release evoked by capsaicin , 100 nM bradykinin, or 40 mM KCl.”
“Response to capsaicin was increased following treatment with the hyperalgesic prostaglandins, PGE2 and PGI2.”
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