Possible Interaction: Capsaicin and Epinephrine

“It is known that capsaicin induces the increase of energy metabolism through adrenaline activation.”

“However, immediately after the pretreatment with epinephrine , the Ca(2+) transients evoked by chemical stimulants ( capsaicin , KCl, and ATP) were markedly potentiated; for example, capsaicin (50 nM, 15 s)-evoked Ca(2+) transient was increased by 106% after epinephrine (P < 0.05; n = 11).”

“Compared with CON, CAP animals demonstrated an 80% suppression in epinephrine levels by minute 105, 7.11 +/- 0.55 nM (P < 0.001).”

“The 15 mg/kg dose of capsaicin significantly (p < 0.05) enhanced the endurance performance time and plasma concentration of epinephrine , norepinephrine, free fatty acid and glucose rose to significantly higher levels within 30 min; swimming exercise compared to rest (p < 0.05).”

“On the other hand, the injection of capsaicin produced protracted increases in adrenal nerve activity and catecholamine secretion both in CNS-intact animals and in animals acutely spinalized at the Cl-2 level.”

“Pretreatment with capsaicin , a potent toxin selective to sensory neurons, potentiated the bombesin-induced increase in plasma level of adrenaline.”

“ Capsaicin induced a release of neuropeptide Y-like immunoreactivity and noradrenaline from both the spleen and the kidney and of adrenaline from the adrenal, but no detectable overflow of endothelin-like immunoreactivity from any of the vascular regions.”

“4 The positive chronotropic and inotropic effects of Ad and nicotine were differentially affected by capsaicin desensitization.”

“The nerve activity began to show an increase with the administration of capsaicin at a dosage of 20 micrograms/kg and significantly increased with a dosage of 200 micrograms/kg, i.e., capsaicin was found to cause a dose-dependent increase in adrenal nerve activity.”