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Discover Supplement-Drug Interactions

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Possible Interaction: Capsaicin and Enkephalin, Ala(2)-Mephe(4)-Gly(5)-

Research Papers that Mention the Interaction

In normal control … slices, capsaicin induced a drastic pERK expression in superficial dorsal horn neurons, which … suppressed by morphine (10 μM), the selective μ-opioid receptor agonist DAMGO [[d-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (1 μM)], and … selective CB1 receptor ACEA agonist [arachidonyl-2′-chloroethylamide (5 μM)].
In the adjacent L4 spinal segment, both DAMGO and ACEA significantly suppressed pERK induction by capsaicin.
Journal of Pharmacology and Experimental Therapeutics  •  2006  |  View Paper