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Last Updated: a year ago

Possible Interaction: Capsaicin and Dopamine

supplement:

Capsaicin

Research Papers that Mention the Interaction

By contrast, treatment with capsaicin (a specific TRPV1 agonist) increased the survival of dopamine neurons in the SN and their fibers and dopamine levels in the STR in MPTP mice.
Journal of immunology research  •  2020  |  View Paper
We found that CAP prevented the degeneration of nigral dopamine neurons in a dose-dependent manner and inhibited the expression of proinflammatory mediators in the LPS-lesioned SN.
Experimental & Molecular Medicine  •  2018  |  View Paper
In brain slices, application of the TRPV1 receptor agonist capsaicin increased the firing rate of rat dopamine neurons and in a proportion of tested cells (44%) it also induced a bursting behavior.
Interestingly, microinjection of capsaicin into the VTA and noxious tail stimulation transiently enhanced dopamine release into the nucleus accumbens.
Neuropsychopharmacology  •  2005  |  View Paper
2 Capsaicin (1 to 30 μm) suppressed dopamine release and the intracellular Ca2+ increase evoked by 100 μm ACh.
Dopamine release evoked by 80 mm KC1 was also suppressed by capsaicin (3 and 30 μm), but the extent of suppression was smaller than that of the ACh‐evoked release.
The concentration‐dependence of the ACh‐evoked release of dopamine was not shifted but the maximal response was reduced by capsaicin.
British journal of pharmacology  •  1994  |  View Paper
The results suggest that delayed treatment of CAP increases nigral TH enzyme activity and striatal levels of DA and its metabolites by CNTF endogenously derived from CAP-activated astrocytes through TRPV1, leading to functional recovery.
Experimental neurobiology  •  2019  |  View Paper