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Last Updated: 3 years ago

Possible Interaction: Capsaicin and Dinoprostone

supplement:

Capsaicin

Research Papers that Mention the Interaction

Results demonstrate that cap (0.1–25 µM) significantly (p < 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2α, and differentially regulated the levels of cytokines (TNF-α, IL-6 & IL-1β).
Scientific Reports  •  2017  |  View Paper
Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2 , a potent inducer of RANKL.
Journal of periodontal research  •  2013  |  View Paper
PGE2 and … of CPS (cough number after PGE2 = 4.20 ± 0.42; p < 0.001, and after BK = 3.64 ± 0.37; p < 0.01), compared to … after PGE2 = 6.1; p < 0.01, and after BK = 4.2; p < 0.05), compared to diluent (2.5–3.3).
Scientific reports  •  2020  |  View Paper
Spontaneously released PGE2 and PGD2 levels were significantly reduced in the presence of capsaicin.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2011  |  View Paper
Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2 , and the stimulated release was attenuated by capsazepine.
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
The mechanisms by which capsaicin stimulates DNA synthesis and production of collagenase and prostaglandin E2 , in a manner dependent on dose, remain to be determined.
Annals of the rheumatic diseases  •  1990  |  View Paper
However, PGE2 significantly increased both responses to capsaicin , the geometric mean (95% Cl) for the dose of capsaicin causing 5 or more coughs being 16.2 (14.3 to 18.3) nmol before and 4.4 (2.4 to 7.9) nmol after PGE2 (p less than 0.05).
The percent increase (95% Cl) in Rrs after capsaicin was 20 (16.5 to 23.5)% before and 37.2 (32.2 to 43.2)% after PGE2 (p less than 0.05).
The American review of respiratory disease  •  1989  |  View Paper
Systemic capsaicin desensitization, which causes degeneration of C-fibers, prevented PGE2 mediated reductions in bladder capacity, suggesting that PGE2 acts as an irritant (Maggi et al.1988).
American journal of physiology. Renal physiology  •  2020  |  View Paper
This facilitatory effect of PGE2 was attenuated by AMG9810 and in neurons desensitized by repeated application of capsaicin.
Brain Research  •  2019  |  View Paper
In cultured dorsal root ganglion (DRG) neurons, we observed that the administration of PGE2 increases capsaicin induced calcium transients, and a pre-incubation of DRG cells with the JAK inhibitor AG490 blocks this PGE2 in vitro effect.
Life sciences  •  2016  |  View Paper
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