Possible Interaction: Capsaicin and Dinoprostone

“Results demonstrate that cap (0.1–25 µM) significantly (p < 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2α, and differentially regulated the levels of cytokines (TNF-α, IL-6 & IL-1β).”

“Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2 , a potent inducer of RANKL.”

“… PGE2 and … of CPS (cough number after PGE2 = 4.20 ± 0.42; p < 0.001, and after BK = 3.64 ± 0.37; p < 0.01), compared to … after PGE2 = 6.1; p < 0.01, and after BK = 4.2; p < 0.05), compared to diluent (2.5–3.3).”

“Spontaneously released PGE2 and PGD2 levels were significantly reduced in the presence of capsaicin.”

“Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2 , and the stimulated release was attenuated by capsazepine.”

“The mechanisms by which capsaicin stimulates DNA synthesis and production of collagenase and prostaglandin E2 , in a manner dependent on dose, remain to be determined.”

“However, PGE2 significantly increased both responses to capsaicin , the geometric mean (95% Cl) for the dose of capsaicin causing 5 or more coughs being 16.2 (14.3 to 18.3) nmol before and 4.4 (2.4 to 7.9) nmol after PGE2 (p less than 0.05).”

“The percent increase (95% Cl) in Rrs after capsaicin was 20 (16.5 to 23.5)% before and 37.2 (32.2 to 43.2)% after PGE2 (p less than 0.05).”

“Systemic capsaicin desensitization, which causes degeneration of C-fibers, prevented PGE2 mediated reductions in bladder capacity, suggesting that PGE2 acts as an irritant (Maggi et al.1988).”

“This facilitatory effect of PGE2 was attenuated by AMG9810 and in neurons desensitized by repeated application of capsaicin.”

“In cultured dorsal root ganglion (DRG) neurons, we observed that the administration of PGE2 increases capsaicin induced calcium transients, and a pre-incubation of DRG cells with the JAK inhibitor AG490 blocks this PGE2 in vitro effect.”