Possible Interaction: Capsaicin and Dietary Fiber

“ Capsaicin overcomes both liabilities by disrupting peripheral terminals of nociceptive fibers that express TRPV1, and thereby affects all of the potential means of activating that pain fiber (not just TRPV1 function).”

“ Capsaicin , the principal ingredient of hot peppers, selectively stimulates C fibre afferents resulting in the release of these proinflammatory peptides.”

“The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.”

“Incubation overnight in a high concentration of capsaicin (3×10−4 M) caused degeneration of SP-LI fibres.”

“ Capsaicin also evoked dose‐dependent glutamate release and depleted SP in fibres within the preBötC. Our results suggest that depletion of SP (or other peptides) and/or glutamate by capsaicin causes a cessation of respiratory rhythm in neonatal rat slices.”

“Morphological studies have demonstrated that neonatal capsaicin treatment (NCT) depletes C‐fiber inputs in the spinal dorsal horn; the electrophysiological features of the NCT‐induced changes, however, remain unclear.”

“CGRP‐IR and SP‐IR fibres were significantly reduced in numbers by the capsaicin treatment (by 58 and 49%, respectively), confirming the success of sensory denervation.”

“Here we demonstrated that selective elimination of C‐fibres by neonatal capsaicin treatment resulted in the disappearance of allodynia induced by PGE2, but not that by PGF2α.”

“Pretreatment of the eye with capsaicin , which is known to cause functional ablation of C‐fibres , inhibited the conjunctival hyperaemia, miosis and AFR by 4050%; the maximal reduction in pupil size being 2.2±0.2 mm and the maximal AFR 13.8±2.1 (arbitrary units) (n=8).”

“It is known … some afferent fibres from the bladder are sensitive to acute administration of capsaicin and to irritant chemicals introduced into the bladder (McMahon and Abel, 1987; H_bler et al, 1988, 1990; Maggi, 1990), and it may be that these substances act on sensory endings in the epithelium.”