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Last Updated: a year ago

Possible Interaction: Capsaicin and Dexamethasone

supplement:

Capsaicin

Research Papers that Mention the Interaction

Dexamethasone antagonized the effects of endotoxin and capsaicin , while NSAID affected mainly the endotoxin-induced inflammation.
Cytokine  •  2009  |  View Paper
Compared to their pre-ozone status on the day of exposure, we found that dexamethasone-pretreated animals manifested significantly less of an increase in airway reactivity postozone to IV SP or inhaled CAP than did untreated animals.
Lung  •  2004  |  View Paper
Furthermore, DFU, NS-398, SC-560, and dexamethasone caused severe injury in the acid-challenged stomach of rats pretreated with capsaicin to ablate afferent neurons.
Journal of Pharmacology and Experimental Therapeutics  •  2004  |  View Paper
Mast cell products are important in the actions of capsaicin, because pretreatment with dexamethasone (4 mg/kg), to eliminate mast cells by a macrophage-dependent mechanism, abrogated the actions of capsaicin.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
Depletion of mucosal mast cells through treatment with dexamethasone also significantly reduced the hyperemic response to capsaicin.
The American journal of physiology  •  1992  |  View Paper
We found that dexamethasone reduced, in a dose-dependent fashion, the magnitude of plasma extravasation produced in the rat trachea by capsaicin and substance P. Significant inhibition was produced by a dose of dexamethasone as small as 0.5 mg/kg i.p.
The Journal of clinical investigation  •  1990  |  View Paper