Possible Interaction: Capsaicin and Cyclosporine

“Furthermore, capsaicin increased the 4-aminopyridine-induced phosphorylation of protein phosphatase calcineurin and the calcineurin inhibitor cyclosporine A eliminated the inhibitory effect of capsaicin on evoked glutamate release.”

“The total clearance (CL/F) of CyA was decreased, and the bioavailability was significantly increased to about 1.44-fold of that in vehicle-treated rats after 7 days of high dose CAP treatment.”

“These results demonstrated that chronic … of high doses of CAP will increase … bioavailability of CyA to a significant extent in rats and the food-drug interaction between CAP and CyA appears to be due to modulation of P-gp and CYP3A gene expression by CAP, with differential dose-dependence.”

“Furthermore, repeated application of cyclosporin A (100 μm) significantly inhibited the contractile response to capsaicin (1 μm).”

“In contrast, ω‐CTX failed to significantly reduce the contractile potency to capsaicin or cyclosporin A. 5 In bronchial preparations desensitized by repeated application of capsaicin (1 μm), the contractile responses to both cyclosporin A (100 μm) and FK506 (100 μm), were significantly reduced.”

“Both FK888 (1 μM) and capsaicin (10 μM), a substance P receptor antagonist and a substance P-depleting agent, respectively, inhibited the contractile effect of cyclosporin A , whereas atropine (1 μM) had no effect.”

“ Capsaicin , the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine.”