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Last Updated: 2 months ago

Possible Interaction: Capsaicin and Cyclosporine

supplement:

Capsaicin

Research Papers that Mention the Interaction

Capsaicin , the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine.
Journal of the American Heart Association  •  2016  |  View Paper
Furthermore, capsaicin increased the 4-aminopyridine-induced phosphorylation of protein phosphatase calcineurin and the calcineurin inhibitor cyclosporine A eliminated the inhibitory effect of capsaicin on evoked glutamate release.
Food & function  •  2017  |  View Paper
The total clearance (CL/F) of CyA was decreased, and the bioavailability was significantly increased to about 1.44-fold of that in vehicle-treated rats after 7 days of high dose CAP treatment.
These results demonstrated that chronic … of high doses of CAP will increase … bioavailability of CyA to a significant extent in rats and the food-drug interaction between CAP and CyA appears to be due to modulation of P-gp and CYP3A gene expression by CAP, with differential dose-dependence.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
Furthermore, repeated application of cyclosporin A (100 microM) significantly inhibited the contractile response to capsaicin (1 microM).
In contrast, omega-CTX failed to significantly reduce the contractile potency to capsaicin or cyclosporin A. In bronchial preparations desensitized by repeated application of capsaicin (1 microM), the contractile responses to both cyclosporin A (100 microM) and FK506 (100 microM), were significantly reduced.
British journal of pharmacology  •  1998  |  View Paper
Both FK888 (1 μM) and capsaicin (10 μM), a substance P receptor antagonist and a substance P-depleting agent, respectively, inhibited the contractile effect of cyclosporin A , whereas atropine (1 μM) had no effect.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1997  |  View Paper