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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Capsaicin
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine was significantly increased by CYP1A2-treated capsaicin in the presence of Cu(II).”
Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper“In the present study, we show that capsaicin is capable of causing strand scission in calf thymus and plasmid DNA in the presence of Cu(II) and that this breakage is mediated by reactive oxygen species, especially the hydroxyl radical.”
“Our results further show that capsaicin can directly generate hydroxyl radicals in the presence of Cu(II).”
“Stoichiometric analysis indicated that whereas 1 mol of capsaicin reduced 3 mol of Cu(II) , 1 mol of DHC reduced only 2 mol of Cu(II).”
Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).
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