“Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-β1 through high doses of corticosterone , indicating direct cellular immunomodulation.”
“The capsaicin treatment further attenuated the immunosuppression induced by the corticosterone treatment (40 mg/kg i.p.”
“These results show, that capsaicin is able to modulate chronic stress-induced immunosuppression, mediating corticosterone released inhibition, but also, that capsaicin significantly modulates the pharmacological action of corticosterone in vivo.”