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Last Updated: a year ago

Possible Interaction: Capsaicin and Corticosterone

supplement:

Capsaicin

Research Papers that Mention the Interaction

Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-β1 through high doses of corticosterone , indicating direct cellular immunomodulation.
The capsaicin treatment further attenuated the immunosuppression induced by the corticosterone treatment (40 mg/kg i.p.
These results show, that capsaicin is able to modulate chronic stress-induced immunosuppression, mediating corticosterone released inhibition, but also, that capsaicin significantly modulates the pharmacological action of corticosterone in vivo.
International immunopharmacology  •  2021  |  View Paper
ConclusionsThese findings suggest that capsaicin inhibits corticosterone production induced by LPS by acting directly on adrenal cells producing glucocorticoids, in a mechanism probably associated with induction of a cytoplasmic calcium increase in these cells.
Y1 cells express TRPV1, measured by immunofluorescence and western blot, and capsaicin decreased LPS-induced corticosterone production by these cells in vitro.
Endocrine  •  2019  |  View Paper
Repeated oral capsaicin increased both the basal level and stress-induced elevation of plasma corticosterone in rats with bilateral transections of the lingual and chorda tympani nerves.
Archives of oral biology  •  2015  |  View Paper
Sciatic nerves were exposed and a 10 mm length was soaked for 15 min in 1.5% … vehicle or in the vehicle alone (10% Tween 80, 10% ethyl alcohol in saline).Both the capsaicin solution and the vehicle … block of the C compound action potential while in … the nerve.
PAIN®  •  1981  |  View Paper