Possible Interaction: Capsaicin and Corticosterone

“Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-β1 through high doses of corticosterone , indicating direct cellular immunomodulation.”

“The capsaicin treatment further attenuated the immunosuppression induced by the corticosterone treatment (40 mg/kg i.p.”

“These results show, that capsaicin is able to modulate chronic stress-induced immunosuppression, mediating corticosterone released inhibition, but also, that capsaicin significantly modulates the pharmacological action of corticosterone in vivo.”

“ConclusionsThese findings suggest that capsaicin inhibits corticosterone production induced by LPS by acting directly on adrenal cells producing glucocorticoids, in a mechanism probably associated with induction of a cytoplasmic calcium increase in these cells.”

“Y1 cells express TRPV1, measured by immunofluorescence and western blot, and capsaicin decreased LPS-induced corticosterone production by these cells in vitro.”

“Repeated oral capsaicin increased both the basal level and stress-induced elevation of plasma corticosterone in rats with bilateral transections of the lingual and chorda tympani nerves.”

“Sciatic nerves were exposed and a 10 mm length was soaked for 15 min in 1.5% … vehicle or in the vehicle alone (10% Tween 80, 10% ethyl alcohol in saline).Both the capsaicin solution and the vehicle … block of the C compound action potential while in … the nerve.”