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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Capsaicin
drug:
Collagenases
Research Papers that Mention the Interaction
“ Capsaicin , a homovanillic acid derivative that acts as a releaser of SP from primary afferent neurons, caused a strong stimulation of collagenase production and release at 10(-8) and 10(-6) M (about 7 times the amount of the control).”
Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.“ Capsaicin at both doses induced an increase in the synthesis of collagenase and at the lower concentration (10(-8) mol/l) only of prostaglandins.”
“The mechanisms by which capsaicin stimulates DNA synthesis and production of collagenase and prostaglandin E2, in a manner dependent on dose, remain to be determined.”
“Curcumin and capsaicin also inhibited the secretion of collagenase , elastase, and hyaluronidase to the maximum extent of 57, 61, 66%, and 46, 69, 67%, respectively.”
Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages
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