Possible Interaction: Capsaicin and Colforsin

“Application of capsaicin (100 μM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 μM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels.”

“ Forskolin application also increased phosphorylated myosin phosphatase target subunit 1, and the phosphorylation was prevented by capsaicin and capsazepine, suggesting that these capsaicinoids assume aspects of Rho kinase inhibitors.”

“Pre-treatment of CB1-VR1-HEK cells with forskolin , an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i.”

“Although capsaicin did not affect the basal expression level of Ucp1, Ucp1 induction by forskolin was partially inhibited by capsaicin , irrespective of the dose of capsaicin.”

“Moreover, forskolin , an adenylate cyclase agonist, selectively decreased the inhibitory effects of IK by capsaicin , whereas none influenced the inhibitions of IA.”

“These effects of forskolin are mimicked by capsaicin , but are in marked contrast to those previously reported for norepinephrine on the action potential and membrane currents (Dunlap and Fischbach 1981).”

“The effects of capsaicin were enhanced by forskolin , pCPT-cAMP, and isobutylmethylxanthine.”

“Consistent with these findings we confirmed that forskolin , a PKA activator, enhances the effect of NGF on the capsaicin response.”

“Exposure of the sensory neuron to either PGE2 or forskolin produced a large and transient increase in the mean channel activity (NPo) elicited by capsaicin , although the unitary conductance remained unaltered.”