Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Capsaicin and Colchicine



Research Papers that Mention the Interaction

One week after pretreatment of the sciatic nerve with colchicine , the number of FOS-LI neurons induced by capsaicin was greatly decreased (by 74.6 +/- 1.7%).
Neurosignals  •  2002  |  View Paper
Colchicine reduced the effects of the first two stimuli by 31% and 33% and, as expected not the effect of substance P. The increase of paw skin temperature following capsaicin i.v. was inhibited by SR-140333, but not by colchicine.
British journal of pharmacology  •  1996  |  View Paper
Bilateral injection of colchicine in the prostatic tissue underneath the pelvic ganglia of male rats induced a time-dependent reduction (maximal at 72 h, 100% reduction) of the in vitro contraction of the bladder strips induced by capsaicin (1 microM).
Neuroscience  •  1996  |  View Paper
After incubation with colchicine there was a marked attenuation of the decline in the prolonged response to CGRP or capsaicin and no development of CGRP tachyphylaxis.
Neuroscience Letters  •  1991  |  View Paper
However, pretreatment of rats with colchicine or vinblastine prolonged the desensitizing effect of local capsaicin application, probably by inhibiting the axonal flow.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1975  |  View Paper