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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Capsaicin
supplement:
Citric Acid
Research Papers that Mention the Interaction
“During long-term challenge cough … over 40 min both with citric acid (100 mM, p less than 0.05; 300 mM, p less ….001; 1 M, p less than 0.001) and with capsaicin (3 microM, p less than 0.01; 10, … microM, p less than 0.001 each).”
Adaptation of cough reflex with different types of stimulation.“There was a positive correlation between the sensitivity to capsaicin and the cough threshold to citric acid (r = 0.69, P = 0.01), and also between the cough latencies (r = 0.67, P = 0.02).”
“Acetazolamide did not affect the irritant sensation from citric acid, while capsaicin pretreatment reduced both the sensation elicited by carbonated water and the irritation induced by citric acid application.”
“There was a significant correlation between the endoscopic score and the citric acid cough threshold before and after daily capsaicin application in the patients.”
“BACKGROUND Inhaled agents, such as ca saicin an d cit ric acid, r eadily produce coughing and the sensation of urge-to-cough.”
“In addition, citric acid self-desensitization and cross-desensitization to capsaicin were observed.”
“The irritant sensation elicited by citric acid increased significantly, indicating a 'cross-stimulus-induced recovery' from capsaicin desensitization.”
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