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Last Updated: a year ago

Possible Interaction: Capsaicin and Carbachol

supplement:

Capsaicin

Research Papers that Mention the Interaction

Capsaicin inhibited catecholamine secretion (IC50=9.5, 11.8, and 62 μM) stimulated by carbachol , an agonist of the nicotinic acetylcholine receptor, by veratridine, an activator of voltage-dependent Na+ channels, and by high K+, an activator of voltage-dependent Ca2+ channels, respectively.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2006  |  View Paper
In a solution containing 0.5 mM Ca2+ and in the presence of carbachol (10 microM) capsaicin evoked a fast concentration-dependent relaxation of the muscle that was usually followed by a smaller, slower, relaxant response.
European journal of pharmacology  •  1998  |  View Paper
However, the increased sensitivity to carbachol and to electrical stimulation seen after capsaicin treatment indicates the development of a supersensitivity to muscarinic receptor stimulation.
The concentration-response curve to carbachol as well as the frequency-response curve to electrical stimulation were significantly shifted to the left in bladder muscle after capsaicin treatment.
Acta physiologica Scandinavica  •  1990  |  View Paper
Capsaicin reduced responses to exogenous substance P or carbachol only partially.
The American journal of physiology  •  1985  |  View Paper