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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Capsaicin inhibited catecholamine secretion (IC50=9.5, 11.8, and 62 μM) stimulated by carbachol , an agonist of the nicotinic acetylcholine receptor, by veratridine, an activator of voltage-dependent Na+ channels, and by high K+, an activator of voltage-dependent Ca2+ channels, respectively.”
Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells“In a solution containing 0.5 mM Ca2+ and in the presence of carbachol (10 microM) capsaicin evoked a fast concentration-dependent relaxation of the muscle that was usually followed by a smaller, slower, relaxant response.”
“However, the increased sensitivity to carbachol and to electrical stimulation seen after capsaicin treatment indicates the development of a supersensitivity to muscarinic receptor stimulation.”
“The concentration-response curve to carbachol as well as the frequency-response curve to electrical stimulation were significantly shifted to the left in bladder muscle after capsaicin treatment.”
“ Capsaicin reduced responses to exogenous substance P or carbachol only partially.”
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