Possible Interaction: Capsaicin and Captopril

“However, captopril significantly shifted the dose-response curve to capsaicin inhalation.”

“In normal subjects, an oral dose of captopril (25 mg) causes a significant shift in the dose-response curve to capsaicin inhalation, but not that to distilled water or citric acid.”

“Pretreatment of guinea pigs with capsaicin (100 μg/kg) slightly suppressed the bronchoconstriction by BK alone and almost all of the enhancement of BK-induced bronchoconstriction by captopril was suppressed.”

“After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung.”

“These responses were inhibited by capsaicin pretreatment and the neurokinin type 1 antagonist N-acetyltrifluoromethyl tryptophan benzyl ester and were potentiated by the peptidase inhibitors phosphoramidon and captopril , suggesting that these responses were mediated by tachykinin.”

“After pretreatment with the NK‐1 receptor antagonist CP 99994 (10−7 M), substance P (10−8 M; P < 0.001) and capsaicin (10−6 M: P < 0.01)‐induced relaxations were reduced.”

“A pretreatment with capsaicin statistically (P < 0.05) enhanced EFS-induced contraction in all tested preparations respect to tissues incubated with atropine, thiorphan and captopril.”

“5 Both low dose SP (1 nmol) and capsaicin (1 nmol)‐induced hyperalgesia were potentiated by the kininase II inhibitor captopril (100 μg).”

“3 Captopril (8–1000 μg kg−1) enhanced dose‐dependently the BC induced by capsaicin.”

“Following a comparable experimental protocol, Long-Evans rats treated neonatally with capsaicin showed a more marked hypotensive response to captopril administration than did vehicle-injected animals.”