Possible Interaction: Capsaicin and Calcium Supplement

“ Capsaicin dose-dependently increased intracellular calcium with an EC50 of 0.29 μM in rTRPV1 expressing HEK293 cells.”

“Binding of capsaicin to this receptor allows both sodium and calcium (and possibly potassium) ions to flow down their concentration gradients, causing initial depolarization and neurotransmitter release.”

“Both CA isozymes were inhibited by capsaicin in the micromolar range.”

“The data demonstrate that VR1 receptor agonists capsaicin and resiniferatoxin lead to a sustained increase in intracellular calcium and sodium in a concentration-dependent manner, followed by cell death.”

“ Capsaicin analogs capsazepine and resiniferatoxin also produce inhibition of CCE via block of I(CRAC).”

“Indo-… that capsaicin … CCE without affecting release of inositol-1,4,5-trisphosphate-sensitive internal Ca2+ stores with an IC50 of 32 microM. Block of Ca2+ entry … CCE is evoked by T-cell receptor (TCR) stimulation, heterologous muscarinic M1 receptor stimulation, or via thapsigargin depletion of internal Ca2+ stores.”

“ Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells.”

“Lidocaine, cadmium, verapamil and capsaicin showed unspecific blocking effects on calcium and tetrodotoxin-resistant potentials.”

“Its IC50 value for inhibiting calcium inflow stimulated by 40 μM capsaicin or 10 μM GSK1702934A was estimated to be around 6 μM. Reduced TRP-V1 or -C6 activity might result in promoting adipogenesis.”

“We observed that capsaicin decreased reticular calcium in a concentration-dependent manner.”

“In vitro, the combined treatment inhibited the increase in intracellular calcium concentration evoked by capsaicin in the dorsal root ganglion neurons.”