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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Capric Acid and Perampanel

supplement:

Capric Acid

Research Papers that Mention the Interaction

Because each compound has been proposed to act through a distinct AMPA receptor binding site, we predicted that perampanel and decanoic acid would act synergistically against AMPA receptors and, consequently, seizures.
Here, we show a synergistic interaction between perampanel and decanoic acid in direct AMPA receptor inhibition, in an ex vivo model of seizure activity, and against seizure‐induced activity in human brain slices.
These data support a potential role for combination treatment using perampanel and dietary decanoic acid to provide enhanced seizure control.
Epilepsia  •  2018  |  View Paper