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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Canrenone
supplement:
Progesterone
Research Papers that Mention the Interaction
“4 Kd for progesterone was 3.2 X 10(-9)M. Ki (the inhibition constant for canrenone with respect to progesterone binding) was 300 X 10(-9)M. Reports in the literature suggest that, following spironolactone administration, canrenone may rise to concentrations sufficiently high to inhibit progesterone binding.”
“There was marked cooperativity in progesterone binding at high canrenone and low progesterone concentrations.”
The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol.
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